Data Submission and Query#

Data Submission Guides for AIRR-seq studies#

There are multiple data repositories that accept submission of AIRR-seq datasets. Each provides different capabilities but all comply with the MiAIRR standard.

National Center for Biotechnology Information (NCBI)

VDJServer Community Data Portal

iReceptor Turnkey Repository

Data Submission for Inferred Genes and Alleles#

In 2017, The AIRR Community established the Inferred Allele Review Committee (IARC) to evaluate inferred alleles for inclusion in relevant germline databases. IARC has worked, together with colleagues at IMGT and the US National Institutes of Health, to establish a systematic submission and review process. OGRDB was created and designed to support that process, and provide a real-time record of affirmed sequences.

Inferred Immune Receptor Genes

Data Query and Download from the AIRR Data Commons#

Submission of AIRR-seq datasets to public data repositories means that other researchers can query, download and reuse that data for novel analyses.

AIRR Data Commons#

The AIRR Data Commons is a network of distributed repositories that store AIRR-seq data and adhere to the AIRR Community standards. We define the AIRR Data Commons as consisting of the set of repositories that both:

More information on repositories in the AIRR Data Commons and how to query these repositories can be found on the AIRR Data Commons page:

Other Public AIRR-Seq Repositories#

There are additional data repositories that provide access to AIRR-seq data but which did not implement the ADC API for programmatic access. Information about some of these repositories are provided in a B-T.CR forum post.

Germline Gene Inference and Usage#

  • OGRDB provides a list of alleles affirmed by the AIRR Community’s Inferred Allele Review Committee, together with supporting information.

  • VDJbase provides gene usage information derived from a growing base of AIRR-seq repertoires, including inferred genotypes and haplotypes.